منابع مشابه
Precursor loss triggers AIDS
In the MyD88 family of cytosolic adaptor proteins, the newest member is the group's black sheep, according to Kim et al. (page 2063). Whereas most MyD88 proteins turn on anti-pathogen responses within myeloid cells, the rebel, MyD88-5, instigates cell death within neurons. MyD88-1–4 all respond to Toll-like receptor (TLR) activation in leuko-cytes and stimulate innate immune responses. MyD88-5,...
متن کاملMicroglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60
Reactive microglia are present in lesions of myelin‑associated white matter disorders resulting in injuries to oligodendrocyte precursor cells (OPCs). Therefore, protection of OPCs from injury due to excessive activation of microglia is important in treating these diseases. Heat shock protein 60 (HSP60) has been demonstrated to be released extracellularly in the failing heart upon stress or inj...
متن کاملDiffuse hair loss: its triggers and management.
Diffuse hair loss can affect both sexes at any age. Anything that interrupts the normal hair cycle can trigger diffuse hair loss. Triggers include a wide variety of physiologic or emotional stresses, nutritional deficiencies, and endocrine imbalances. Loss of telogen-phase hairs is the most common. Hair loss during the anagen phase is usually caused by chemotherapy or radiation therapy. Finding...
متن کاملStigma Regarding Hearing Loss and Hearing Aids
Stigma regarding hearing loss and hearing aids presents a great challenge, especially because dealing with its consequences in an appropriate and timely manner might be associated with better outcomes for the person with hearing loss, their caregivers, and society. A clear understanding of the stigma concept and its measurement in the area of hearing loss among older adults might advance knowle...
متن کاملLoss of KLF14 triggers centrosome amplification and tumorigenesis
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional repressor of Plk4, a polo-like kinase whose overexpression induces centrosome overduplication. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2007
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2049iti2